Acquired immunologic tolerance: with particular reference to transplantation

Acquired immunologic tolerance: with particular reference to transplantation.

The first unequivocally successful bone marrow cell transplantation in humans was recorded in 1968 by the University of Minnesota team of Robert A. Good (Gatti et al. Lancet 2: 1366-1369, 1968). This achievement was a direct extension of mouse models of acquired immunologic tolerance that were established 15 years earlier. In contrast, organ (i.e. kidney) transplantation was accomplished precoc...

Liver transplantation, 1980, with particular reference to cyclosporin-A.

Induction of immunologic tolerance for transplantation.

In the second half of the 20th century, the transplantation of replacement organs and tissues to cure disease has become a clinical reality. Success has been achieved as a direct result of progress in understanding the cellular and molecular biology of the immune system. This understanding has led to the development of immunosuppressive pharmaceuticals that are part of nearly every transplantat...

Cell migration and chimerism--a unifying concept in transplantation--with particular reference to HLA matching and tolerance induction.

WE recently reported that the acceptance of wholeorgan transplants connotes (and requires) a special kind of mixed chimerism involving an exchange between organ and recipient oflymphodendritic leukocytes (Fig 1 ).1 The consequence in five of five patients studied 27 to 29V2 years after kidney transplantation from HLA-mismatched donors was the diffuse presence of donor dendritic cells in the lym...

Constrictive pericarditis with particular reference to etiology.